UroToday - Risk factors for female pelvic floor disorders include aging, obesity, multiparity, and genetics. Dr. Larissa Rodriguez and the UCLA group have demonstrated that environmental effects and genetics each contribute an approximate 40% increased risk of development of pelvic prolapse, which appears to be inherited in an autosomal dominant fashion with high penetrance.

Future directions include focus on genetic defects, screening populations at risk for pelvic prolapse, environmental modifications (e.g. elective Cesaerean section) in patients deemed to be at increased risk, and development of targeted therapy.

Presented by: Larissa V. Rodriguez, MD at the Society for Urodynamics and Female Urology (SUFU) 2008 Winter Meeting - February 28 - March 2, 2008 Miami, Florida, USA

Reported by Kathleen Kobashi, MD - Head, Section of Urology and Renal Transplantation, Co-Director of The Virginia Mason Medical Center Continence Center - Seattle, WA USA and Clinical Associate Professor of Urology at the University of Washington - Seattle, WA USA

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